НЕКОТОРЫЕ ВИДОСПЕЦИФИЧЕСКИЕ ОСОБЕННОСТИ НАИБОЛЕЕ ПОПУЛЯРНЫХ ЛАБОРАТОРНЫХ ЖИВОТНЫХ МОДЕЛЕЙ, ВЛИЯЮЩИЕ НА РЕЗУЛЬТАТИВНОСТЬ ПРЕКЛИНИЧЕСКИХ ИСПЫТАНИЙ БИОДЕГРАДИРУЕМЫХ СОСУДИСТЫХ ПРОТЕЗОВ МАЛОГО ДИАМЕТРА (ОБЗОР ЛИТЕРАТУРЫ)

Основные положения

На рынке изделий для нужд сердечно-сосудистой хирургии отсутствуют эффективные сосудистые протезы диаметром менее 4 мм. Биодеградируемые протезы с пролонгированной резорбцией и регенеративным потенциалом рассматриваются как альтернатива. Полнота оценки рисков таких протезов в преклинических испытаниях зависит от выбранной животной модели.

Резюме

На рынке изделий для нужд сердечно-сосудистой хирургии до сих пор не существует эффективного сосудистого протеза диаметром менее 4 мм. Альтернативой может стать биодеградируемый сосудистый протез, обладающий пролонгированной резорбцией и способностью к регенерации. Полнота определения рисков несостоятельности биодеградируемых протезов сосудов малого диаметра, подвергаемых преклиническим испытаниям, напрямую зависит от животной модели, выбранной для проведения подобных испытаний. В данном литературном обзоре представлены основные тенденции последних лет по выбору животных моделей для проведения преклинических испытаний биодеградируемых сосудистых протезов малого диаметра и оценены результативность испытаний в разрезе видоспецифических особенностей наиболее популярных мелких и крупных животных моделей.

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