SPECIES-SPECIFIC CHARACTERISTICS OF WIDELY USED LABORATORY ANIMAL MODELS AND THEIR IMPACT ON THE EFFICACY OF PRECLINICAL STUDIES FOR SMALL-DIAMETER BIODEGRADABLE VASCULAR PROSTHESES (A REVIEW)

Highlights

Effective vascular grafts with diameters less than 4 mm remain unavailable on the market for cardiovascular surgery applications. Biodegradable grafts featuring prolonged resorption and regenerative potential are considered a viable alternative. The comprehensiveness of risk assessment for such grafts in preclinical trials is contingent upon the selected animal model.

Abstract

There is still no effective vascular prosthesis with a diameter of less than 4 mm on the market of products for the needs of cardiovascular surgery. A biodegradable vascular prosthesis with prolonged resorption and regenerative capacity may be an alternative. The completeness of determining the risks of failure of biodegradable prostheses of small-diameter vessels subjected to preclinical tests directly depends on the animal model chosen for such tests. This literature review presents the main trends in recent years in the selection of animal models for preclinical testing of biodegradable vascular prostheses of small diameter and evaluates the effectiveness of tests in the context of species-specific features of the most popular small and large animal models.

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