THE CLINICAL SIGNIFICANCE Of INSULIN-LIKE GROWTH FACTOR-1 IN ACUTE CORONARY SYNDROME
https://doi.org/10.17802/2306-1278-2016-4-52-58
Abstract
Purpose. To analyze levels of insulin-like growth factor-1 (IGF-I) in plasma in patients with acute coronary syndrome.
Materials and methods. The identification of concentrations of IGF-I in 71 patients with acute coronary syndrome, comparison groups and control.
Results. IGF-I in myocardial infarction is lower than in the comparison group. Increased IGF-I in unstable angina pectoris has no significant differences with control groups and comparisons. The highest IGF-I levels in the comparison group, the lowest in cases of mortality. Patients older age group have lower concentrations of IGF-I and lower regenerative capabilities to repair damaged vascular wall and myocardium. In the aspect of the «cardiovascular continuum» reparative role of IGF-I is also defined for acute kidney injury in patients with ACS. Correlation of IGF-I with the basic laboratory parameters of renal system reflect the nature of the protein impact, an opportunity for an expanded range of applications. IGF-I in patients with ACS within the first 24 hours acts as a vector of mortality.
Conclusions. IGF-I is a new highly sensitive biochemical marker of vascular inflammation and damage, can be used in the laboratory diagnosis of acute coronary syndrome. IGF-I levels decline with increasing age of patients with ACS. In the aspect of the «cardiovascular continuum» reparative role of IGF-I is systemic in nature, exerting its beneficial effects on the kidneys.
About the Authors
G. H. KAYUMOVA
Public Limited Company BM Clinic. Ulyanovsk, Russia
Federal State Educational Institution of higher Education Ulyanovsk State University. Ulyanovsk, Russia
Russian Federation
Russian Federation
Address: 93, Promyshlennaya st., Ulyanovsk, 432045, Russian Federation Tel.: +7-937-275-54-91
V. A. RAZIN
Federal State Educational Institution of higher Education Ulyanovsk State University. Ulyanovsk, Russia
Russian Federation
Russian Federation
References
1. 2015 – the year of fight against cardiovascular diseases in Russia [Internet]. Medaboutme.ru [updated 2015 December 18; cited 2016 February 20]. Available from: https://medaboutme.ru/zdorove/publikacii/stati/kardiorisk.
2. Cardiovascular disease in the world. Epidemiology of coronary heart disease [Internet]. MedUniver.com [cited 2016 Februar 20]. Available from: http://meduniver.com/Medical/cardiologia/1294.html
3. Fact sheet № 317 [Internet]. World Health Organization: [updated 2015 Janur, cited 2016 February 20]. Available from: http://www.who.int/mediacentre/factsheets/fs317/ru.
4. Dzau V., Braunwald E. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement. Am. Heart J. 1991; 121 (4 Pt 1): 1244–1263.
5. Li X. PAPP-A: a possible pathogenic link to the instability of atherosclerotic plaque. Med. Hypotheses. 2008; 70: 597–599.
6. Lund J. Circulating pregnancy-associated plasma protein: A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation. 2003; 108: 1924–1926.
7. Шевченко О. П., Слесарева Ю. С., Шевченко А. О. Роль РАРР-А в развитии повреждения атеросклеротической бляшки у больных ишемической болезнью сердца. Российский кардиологический журнал. 2011; 2 (88): 66–67. Shevchenko O. P., Slesareva Yu. S., Shevchenko A. O. The role of PAPP-A in the development of atherosclerotic plaque damage in patients with coronary heart disease. Journal of Cardiology. 2011; 2 (88): 66–67. [In Russ.].
8. Consuegra-Sanchez L. Prognostic value of circulating pregnancy-associated plasma protein-A and proform of eosinophil major basic protein levels in patients with chronic stable angina pectoris. Clin. Chim. Acta. 2008; 391: 18–23.
9. Insulin-like Growth Factor-I (E3R) human >95 % (HPLC), recombinant, expressed in E. coli, lyophilized powder [Internet]. Sigma-Aldrich: Available from: http://www.sigmaaldrich.com/catalog/product/sigma/I2656?lang=en®ion=RU.
10. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network [Internet]. Pubmed.gov: Available from: http://www.ncbi.nlm.nih.gov/pubmed/20849947.
11. Каюмова Г. Х., Разин В. А. Анализ маркеров роста и повреждения при остром коронарном синдроме. Kардиология Узбекистана. 2015; 2: 169. Kayumova G. H., Razin V. A. Analysis of the growth and damage markers in acute coronary syndrome. Cardiology of Uzbekistan J. 2015; 2: 169. [In Russ.].
12. Разин В. А., Каюмова Г. Х., Чернышева Е. В. Протеин плазмы при остром коронарном синдроме. Ульяновский медико-биологический журнал. 2013; 4: 16–19. Razin V. A., Kayumova G. H., Сhernisheva E. V. Plasma protein in acute coronary. Ulyanovsk biomedical. J. 2013; 4: 16–19. [In Russ.].
13. Разин В. А., Чернышева Е. В., Каюмова Г. Х. и др. Маркеры фиброза миокарда при остром коронарном синдроме. Ульяновский медико-биологический журнал. 2014; 1: 19–24. Razin V. A., Сhernisheva E. V., Kayumova G. H. et al. Markers of myocardial fibrosis in acute coronary syndromes. Ulyanovsk biomedical. J. 2014; 1: 19–24. [In Russ.].
14. Сапожников А. Н., Разин В. А., Каюмова Г. Х. и др. Ассоциированный с беременностью протеин плазмы А при остром коронарном синдроме. Саратовский научно-медицинский журнал. 2014; 1: 92–95. Sapozhnikov A. N., Razin V. A., Kayumova G. H. et al. Pregnancy of associated plasma protein A with acute coronary. Saratov. Scientific. MJ. 2014; 1: 92–95. [In Russ.].
Review
For citations:
KAYUMOVA G.H., RAZIN V.A. THE CLINICAL SIGNIFICANCE Of INSULIN-LIKE GROWTH FACTOR-1 IN ACUTE CORONARY SYNDROME. Complex Issues of Cardiovascular Diseases. 2016;(4):52-58. (In Russ.) https://doi.org/10.17802/2306-1278-2016-4-52-58
Views:
719
