THE RELATIONSHIP OF DIABETES WITH PROINFLAMMATORY STATUS IN STEMI FEMALES AND MALES
https://doi.org/10.17802/2306-1278-2014-1-42-46
Abstract
The purpose. The purpose of our research was to study the role of diabetes mellitus in the inflammatory response of males and females with ST-elevation myocardial infarction (STEMI).
Materials and methods. The study enrolled 223 patients with STEMI – 167 (74,9 %) males and 56 (25,1 %) females. The mean male age was 57,1 (51; 62) years and the mean female age was 61,8 (57; 71) years (р = 0,00). The inflammatory marks were measured 10–14 days after STEMI (IL – 1α, 6, 8, 10, 12, CRP, TNFα, sCD40L, NT-proBNP, Neopterin).
Results. The research showed that diabetes mellitus is more often diagnosed in females than males. The females and males with diabetes mellitus had a similar levels of the inflammatory marks (IL – 1α, 6, 8, 10, 12, CRP, TNFα, sCD40L, NT-proBNP, Neopterin). However, females without diabetes mellitus had a higher level of IL-12 than males without diabetes mellitus (р = 0,00). The level of IL-1α in females with diabetes mellitus was higher than in females without diabetes mellitus (р = 0,04).
Conclusion. We assumed that diabetes mellitus in STEMI females was associated with a higher level of the inflammatory response than in females without diabetes mellitus. Diabetes mellitus eliminates gender differences in the inflammatory response.
About the Authors
E. V. Tavlueva
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово
Russian Federation
Russian Federation
Dr. Med. Sci.
leading research associate of pathophysiology laboratory
Correspondence address:
6, Sosnoviy blvd., Kemerovo, 650002. Tel. +7 (3842) 64-45-93
A. P. Yarkovskaya
Муниципальное бюджетное учреждение здравоохранения «Кемеровский кардиологический диспансер», Кемерово
Russian Federation
Russian Federation
O. L. Barbarash
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово
Russian Federation
Russian Federation
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Review
For citations:
Tavlueva E.V., Yarkovskaya A.P., Barbarash O.L. THE RELATIONSHIP OF DIABETES WITH PROINFLAMMATORY STATUS IN STEMI FEMALES AND MALES. Complex Issues of Cardiovascular Diseases. 2014;(1):42-46. (In Russ.) https://doi.org/10.17802/2306-1278-2014-1-42-46
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