THE CEREBRAL PERFUSION OF CIRCULATION DISTURBANCES. PART II (CT- AND MRI SEMIOTICS, PATTERNS OF PATHOLOGICAL CHANGES). REVIEW

The second part of a review article devoted to a detailed consideration of the issues of diagnostic semiotics of acute disorders of cerebral circulation using CT and MR perfusion study techniques. We consider the physiological aspects of formation of the basic parameters of tissue perfusion: of cerebral blood Șow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) contrast, as well as patterns of pathological changes in these parameters (hypo-, hyper- and aperfusion), developing in various degrees of brain ischemic damage and penumbra areas. It is noted that the improvement of MRI using for tissue classi⠇cation of perfusion-diநusion (PWI/DWI) mismatch has a better chance of primary development due to the fact that it non-radiation exposure and is not connected with the need to introduce a large contrast volume, and with the introduction of non-contrast arterial spin labeled technique (ASL). Variants of events in the dynamics of perfusion as a result of reperfusion therapy. There were discussed the problems limiting the use of perfusion techniques in clinical practice.

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