COPEPTIN AND BIOMARKERS OF INFLAMMATION IN PATIENTS WITH DIFFERENT TYPES OF ACUTE CORONARY SYNDROME

Aims. To assess levels of copeptin, inflammatory biomarkers and determine the relationships in patients with myocardial infarction and unstable angina.

Methods. 49 male patients with acute coronary syndrome were included in the study. Patients with myocardial infarction (n=26) aged 64.2±1.6 years were included in Group 1. Patients with unstable angina (n=23) aged 62.1±2.2 years were included in Group 2. The control group (n=20, mean age 57.5 ± 3.3) is represented by healthy subjects without coronary artery disease. Levels of copeptin, endothelin 1, proinflammatory cytokines (IL1 b, IL-6, TNF) were measured in the study groups. The relationships between different clinical, morphological and laboratory parameters were assessed.

Results. Levels of copeptin increased 1 hour after hospital admission in patients with myocardial infarction compared to the control group. Significant increase in copeptin levels was observed 12 hours after hospital admission in patients with myocardial infarction. Therefore, copeptin levels should be measured at a time of hospital admission and 12 hours after it. Levels of IL 1b and IL 6 on day 1 of hospital admission in patients with acute coronary syndrome exceeded reference values. Moreover, a further increase in IL 1b levels on day 6 after myocardial infarction has been observed.

Conclusions. The obtained data confirm the possibility of using copeptin to exclude or confirm myocardial damage, in addition to troponin and serial assessments.

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