Metabolism of cardiac troponins (literature review)
https://doi.org/10.17802/2306-1278-2019-8-4-103-115
Abstract
The review summarizes all recent data on the metabolism of cardiac troponin isoforms. The main mechanisms of troponin release from intact myocardium are described. These mechanisms ensure its baseline levels (less than the 99th percentile) in all healthy individuals. There are various fragments of troponin that circulate in the blood flow as a heterogeneous pool. Their circulation is related to various intracellular and extracellular proteases. In-depth understanding ofthese mechanisms is required to improve the diagnostic process. The article provides new insights into the evaluation of cardiac troponins in other human biological fluids: pericardial, cerebrospinal, amniotic, urine, and oral fluid. The measurements of saliva and urine levels of troponins seem to be promising alternative for non-invasive diagnosis. Recent circadian patterns of high-sensitive cardiac troponin T alterations are reported. These patterns should be taken into account while practicing fast diagnostic algorithms.
About the Authors
A. M. Chaulin
Samara Regional Cardiology Dispensary; Federal State Educational Institution “Samara State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests: not
Russian Federation
Chaulin Aleksey M. - MD, pathologist at the Clinical and Diagnostic Laboratory SRCD; lecturer assistant at the Department of Histology and Embryology SSMU.
43 Aerodromnaya St., Samara, 443070; 89 Chapayevskaya St., Samara, 443099; +7 (927) 770-25-87
Competing Interests: not
L. S. Karslyan
Samara Regional Cardiology Dispensary; Federal State Educational Institution “Samara State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests: not
Russian Federation
Karslyan Lilia S. - PhD, Head of the Clinical and Diagnostic Laboratory SRCD; Associate Professor at the Department of Basic and Clinical Biochemistry SSMU.
43 Aerodromnaya St., Samara, 443070; 89 Chapayevskaya St., Samara, 443099
Competing Interests: not
E. V. Grigorieva
Samara Regional Cardiology Dispensary
Russian Federation
Competing Interests: not
Russian Federation
Grigorieva Ekaterina V. - MD, pathologist at the Clinical and Diagnostic Laboratory.
43 Aerodromnaya St., Samara, 443070
Competing Interests: not
D. A. Nurbaltaeva
Samara Regional Cardiology Dispensary
Russian Federation
Competing Interests: not
Russian Federation
Nurbaltaeva Dona A. - MD, pathologist at the Clinical and Diagnostic Laboratory.
43 Aerodromnaya St., Samara, 443070
Competing Interests: not
D. V. Duplyakov
Samara Regional Cardiology Dispensary; Federal State Educational Institution “Samara State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests: not
Russian Federation
Duplyakov Dmitrii V. - PhD, Director Deputy for Medical Issues SRCD; Professor at the Department of Cardiology and Cardiovascular Surgery SSMU.
43 Aerodromnaya St., Samara, 443070; 89 Chapayevskaya St., Samara, 443099
Competing Interests: not
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Review
For citations:
Chaulin A.M., Karslyan L.S., Grigorieva E.V., Nurbaltaeva D.A., Duplyakov D.V. Metabolism of cardiac troponins (literature review). Complex Issues of Cardiovascular Diseases. 2019;8(4):103-115. (In Russ.) https://doi.org/10.17802/2306-1278-2019-8-4-103-115
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