Modern concepts of orthostatic hypotension
https://doi.org/10.17802/2306-1278-2019-8-4-116-126
Abstract
Recent literary data reports an increase in the prevalence of orthostatic hypotension (ОН) with age and with the presence of comorbidities. In addition, ОН is associated with a high risk of major adverse cardiovascular and cerebrovascular events and may contribute to cognitive impairment and the onset of dementia. Moreover, OH is one of the main risk factors for falls, especially among elderly patients. The review covers recent national and foreign studies focusing on this problem, and presents an updated definition of ОН, its modern classification, pathophysiology, peculiarities of the ОН course in the elderly, guidelines on OH diagnosis and treatment. Particular attention is given to the secondary ОН, commonly known as drug-induced ОН. Its prevalence increases with increased number of medications taken. A list of drugs that may induce ОН and treatment approaches to polypragmasia are provided.
About the Authors
M. M. Petrova
Krasnoyarsk State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests: not
Russian Federation
Petrova Marina M. - PhD, Ршfessor at the Department of Outpatient Care and Family Medicine.
Partizan Zheleznyak st. 1, Krasnoyarsk, 660022Competing Interests: not
O. D. Ostroumova
I.M. Sechenov First Moscow State MedicalUniversity; Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation - Russian Gerontological Research and Clinical Center
Russian Federation
Competing Interests: not
Russian Federation
Ostroumova Olga D. - PhD, Professor at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov MSMU; Head of the Laboratory of Clinical Pharmacology and Pharmacotherapy RGR CC.
Bolshaya Pirogovskaya st. 2/4, Moscow, 119435; 1 Leonova st. 16, Moscow, 129226
Competing Interests: not
M. S. Cherniaeva
Central State Medical Academy of the Department of Presidential Affairs
Russian Federation
Competing Interests: not
Russian Federation
Cherniaeva Marina S. - PhD, Associate Professor at the Department of Internal Medicine and Preventive Medicine.
Marshal Timoshenko st. 19/1A, Moscow, 121359; phone +7 (964) 587-30-03
Competing Interests: not
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For citations:
Petrova M.M., Ostroumova O.D., Cherniaeva M.S. Modern concepts of orthostatic hypotension. Complex Issues of Cardiovascular Diseases. 2019;8(4):116-126. (In Russ.) https://doi.org/10.17802/2306-1278-2019-8-4-116-126
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