MONOCYTE SUBSETS IS A PREDICTOR OF SEVERE COMPLICATIONS OF SYSTEMIC INFLAMMATORY RESPONSE AFTER CORONARY BYPASS SURGERY
https://doi.org/10.17802/2306-1278-2014-4-5-12
Abstract
Purpose. The study was examining of dynamics blood monocyte subsets from patients with different severity of Systemic Inflammatory Response Syndrome (SIRS) after coronary bypass surgery.
Materials and methods. In retrospect, all of the patients in accordance with severity of the SIRS were divided into three groups (1 – uncomplicated SIRS, 2 – complicated SIRS with compensated Multiple Organ Dysfunction Syndrome (MOD S), 3 – complicated SIRS with decompensated MOD S). SIRS confirmed by objective clinical and laboratory parameters, as well as the presence of hypercytokinemia. Each group was estimated dynamics of monocyte subsets (CD14hiCD16–, CD14hiCD16+and CD14dimCD16++) by laser flow cytometer before surgery and 1st and 7th day after surgery.
Results. On the first day after surgery patients of the all groups was detected the activation of monocytes with the redistribution of their subpopulation composition (decrease in the relative content subset of CD14hiCD16– and increase inCD14hiCD16+). At the same time, patients of the third group (SIRS with developed in the future decompensated MOD S) subset CD14hiCD16–was lower and CD14hiCD16 + was higher than in the other groups. Found correlation of the SOF A estimates and the relative proportions blood monocytes CD14hiCD16– andCD14hiCD16+.
Conclusion. In the first days after coronary bypass surgery relative proportion subsets CD14hiCD16+and CD14hiCD16–may be diagnostic and prognostic markers of the severe SIRS and developed in the future decompensated MOD S.
About the Authors
V. G. Matveeva
Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
PhD
senior research associate of cellular technologies laboratory of experimental and clinical cardiology department
Correspondence address:
V. G. Matveeva, 6, Sosnoviy blvd., Kemerovo, 650002. Tel.: +7 (3842) 64-41-56
A. S. Golovkin
Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
E. V. Grigoriev
Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
References
1. Варианты развития острого системного воспаления / Е. Ю. Гусев [и др.] // Цитокины и воспаление. 2008. Т. 7, № 2. C. 9–17.
2. Гусев Е . Ю., Черешнев В . А ., Юрченко Л . Н. Системное воспаление с позиции теории типового патологического процесса // Цитокины и воспаление. 2007. Т. 6, № 4. С. 9–21.
3. Методология изучения системного воспаления / Е. Ю. Гусев [и др.] // Цитокины и воспаление. 2008. Т 7, № 1. C. 15–23.
4. Синдром полиорганной недостаточности у больных после операций в условиях искусственного кровообращения / М. А. Бабаев [и др.]. // Хирургия. 2013. № 2. С. 119–123.
5. Чаленко В . В . Классификация острых нарушений функций органов и систем при синдроме полиорганной недостаточности // Анестезиология и реаниматология. 1998. № 2. С. 25–30.
6. Черешнев В . А ., Гусев Е . Ю. Иммунологические и патофизиологические механизмы системного воспаления // Медицинская иммунология. 2012. Т. 14, № 1–2. С. 9–20.
7. Ярилин А . А . Иммунология. М. ГЭОТАР-Медиа, 2010. 752 с
8. Bone R. С., Sibbald W. J., Sprung С. L. The ACCP-SCCM consensus conference on sepsis and organ failure // Сhest. 1992. Vol. 101, № 6. P. 1481–1483.
9. Evidence of systemic cytokine release in patients undergoing cardiopulmonary bypass / J. Halter [et al.] // J. Extra Corpor. Technol. 2005. Vol. 37, № 3. P. 272–277.
10. Hirai S. Systemic Inflammatory Response Syndrome afterCardiac Surgery under Cardiopulmonary Bypass // Ann. Thorac. Cardiovasc. Surg. 2003. Vol. 9(6). P. 365–370.
11. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors / J. Cros. [et al.] // Immunity 2010. Vol. 33, № 3. P. 375–386.
12. Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery / F. Tacke [et al.] // J. ExP. Med. 2006. Vol. 203, № 3. P. 583–597.
13. Monocyte heterogeneity in human cardiovascular disease / A. M. Zawada [et al.] // Immunobiology. 2012. Vol. 217, № 12. P. 1273–1284.
14. Nomenclature of monocytes and dendritic cells in blood / L. Ziegler-Heitbrock [et al.] // Blood. 2010. Vol. 116 (16). P. 74–80.
15. Perioperative serum levels of tumour-necrosis-factor alpha (TNF-alpha), IL-1 beta, IL-6, IL-10 and soluble IL-2 receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution / A. Roth-Isigkeit [et al.] // Clin. Exp. Immunol. 1999. Vol. 118, № 2. P. 242–246.
16. Piccinini A. M., Midwood K. S. DAM Pening inflammation by modulating TLR signaling // Mediators of Inflammation. 2010. – pii : 672395.
17. Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens / N. A. Skinner [et al.] // Clin. Exp. Immunol. 2005. Vol. 141(2). P. 270–278.
18. Senescent CD14+ CD16+ Monocytes Exhibit Proinflammatory and Proatherosclerotic Activity / A Merino [et al.] // J. Immunol. 2010. Vol. 186. P. 1809–1815.
19. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation // J. Leukocyte. Biology. 2007. Vol. 81, issue 3. P. 584–592.
Review
For citations:
Matveeva V.G., Golovkin A.S., Grigoriev E.V. MONOCYTE SUBSETS IS A PREDICTOR OF SEVERE COMPLICATIONS OF SYSTEMIC INFLAMMATORY RESPONSE AFTER CORONARY BYPASS SURGERY. Complex Issues of Cardiovascular Diseases. 2014;(4):5-12. (In Russ.) https://doi.org/10.17802/2306-1278-2014-4-5-12
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