Preview

Complex Issues of Cardiovascular Diseases

Advanced search

2020 Russian and European clinical practice guidelines for the management of NSTEMI patients: have approaches to antithrombotic therapy been simplified?

https://doi.org/10.17802/2306-1278-2021-10-2-92-101

Abstract

Highlights. Prescribtion patterns of antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndromes have been comapred in 2020 Russian and European clinical practice guidelines for the management of NSTEMI patients.

A comparative assessment of novel approaches of antiplatelet and anticoagulant therapy recommended in 2020 European and Russian clinical practice guidelines for the management of patients with non-ST-segment elevation acute coronary syndrome is reported. In prescribing antiplatelet therapy, ESC guidelines suggest focusing attention on a more complex set of regimens to balance ischemic and hemorrhagic risks. Approaches to prescribing anticoagulant therapy do not differ in the recommendations of two medical societies. Fondaparinux has compelling advantages over other drugs regarding the combination of efficacy and safety in patients.

About the Authors

O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation

Barbarash Olga L. - Ph.D., Professor, Corresponding Member of the Russian Academy of Sciences, Director of the Research Institute for Complex Issues of Cardiovascular Diseases.

6, Sosnoviy blvd., Kemerovo, 650002.


Competing Interests:

О.Л. Барбараш и В.В. Кашталап входят в редакционную коллегию журнала «Комплексные проблемы сердечно-сосудистых заболеваний».



V. V. Kashtalap
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation

Kashtalap Vasily V. - MD, Ph.D., Head of the Department of Clinical Cardiology of the Research Institute for Complex Issues of Cardiovascular Diseases.

6, Sosnoviy blvd., Kemerovo, 650002.


Competing Interests:

О.Л. Барбараш и В.В. Кашталап входят в редакционную коллегию журнала «Комплексные проблемы сердечно-сосудистых заболеваний».



References

1. Kashtalap VV, Barbarash OL. Actual problems of antithrombotic therapy in acute coronary syndrome (following the material presented at the European society of cardiology congress 2017). Medical Council. 2017; 12: 8288. (In Russian)

2. Healthcare in Russia. 2017: statistical collection. Moscow: Rosstat; 2019.170 p (In Russian)

3. Oganov R.G., Kontsevaya A.V., Kalinina A.M. Economic burden of cardiovascular disease in the Russian Federation. Cardiovascular Therapy and Prevention. 2011;10(4):4-9. (In Russian) doi:10.15829/1728-8800-2011-4-4-9

4. Klinicheskie rekomendacii. Ostryj koronarnyj sindrom bez pod"ema segmenta ST elektrokardiogrammy. Available at: http://cr.rosminzdrav.ru/schema/154_3 (accessed 12.02.2021) (In Russian)

5. Collet J.P., Thiele H., Barbato E., Barthelemy O., Bauersachs J., Bhatt D.L., Dendale P., Dorobantu M., Edvardsen T., Folliguet T., Gale C.P., Gilard M., Jobs A., Juni P., Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten F.H., Sibbing D., Siontis G.C.M.; ESC Scientific Document Group. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289-1367. doi: 10.1093/eurheartj/ehaa575.

6. Rex S., Beaulieu L.M., Perlman D.H., Vitseva O., Blair P.S., McComb M.E., Costello C.E., Freedman J.E. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. ТНготЬ Haemost. 2009;102(1):97-110. doi: 10.1160/ТН08-08-0513.

7. Wallentin L., Becker R.C., Budaj A., Cannon C.P., Emanuelsson H., Held C., Horrow J., Husted S., James S., Katus H., Mahaffey K.W., Scirica B.M., Skene A., Steg P.G., Storey R.F., Harrington R.A.; PLATO Investigators, Freij A, 'thorsen M. ficagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57. doi: 10.1056/NEJMoa0904327.

8. Wiviott S.D., Braunwald E., McCabe C.H., Montalescot G., Ruzyllo W., Gottlieb S., Neumann F.J., Ardissino D., De Servi S., Murphy S.A., Riesmeyer J., Weerakkody G., Gibson C.M., Antman E.M.; TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001-15. doi: 10.1056/NEJMoa0706482.

9. Schupke S., Neumann F.J., Menichelli M., Mayer K., Bernlochner I., Wohrle J., Richardt G., Liebetrau C., Witzenbichler B., Antoniucci D., Akin I., Bott-Flugel L., Fischer M., Landmesser U., Katus H.A., Sibbing D., Seyfarth M., Janisch M., Boncompagni D., Hilz R., Rottbauer W., Okrojek R., Mollmann H., Hochholzer W., Migliorini A., Cassese S., Mollo P., Xhepa E., Kufner S., Strehle A., Leggewie S., Allali A., Ndrepepa G., Schuhlen H., Angiolillo D.J., Hamm C.W., Hapfelmeier А., То^ R., Тгепк D., Schunkert H., Laugwitz K.L., Kastrati A.; ISAR-REACT 5 Тпа1 Investigators. Ticagre1or or Prasugrel in Patients with Acute Coronary Syndromes. N Engl J Med. 2019;381(16):1524-1534. doi: 10.1056/NEJMoa1908973.

10. Costa F., van Klaveren D., James S., Heg D., Raber L., Feres F., Pilgrim Т., Hong M.K., Kim H.S., Colombo A., Steg P.G., Zanchin Т., Palmerini Т., Wallentin L., Bhatt D.L., Stone G.W., Windecker S., Steyerberg E.W., Valgimigli M.; PRECISE-DAPT Study Investigators. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials. Lancet. 2017;389(10073):1025-1034. doi: 10.1016/S0140-6736(17)30397-5.

11. Mehran R., Baber U., Sharma S.K., Cohen D.J., Angiolillo D.J., Briguori C., Cha J.Y., Collier Т., Dangas G., Dudek D., Dzavlk V., Escaned J., Gil R., Gurbel P, Hamm C.W., Henry Т., Huber K., Kastrati A., Kaul U., Kornowski R., Krucoff M., Kunadian V., Marx S.O., Mehta S.R., Moliterno D., Ohman E.M., Oldroyd K., Sardella G., Sartori S., Shlofmitz R., Steg P.G., Weisz G., Witzenbichler B., Han Y.L., Pocock S., Gibson C.M.. ^cagre^r with or without Aspirin in High-Risk Patients after PCI. N Engl J Med. 2019;381(21):2032-2042. doi: 10.1056/NEJMoa1908419

12. Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators, Yusuf S., Mehta S.R., Chrolavicius S., Afzal R., Pogue J., Granger C.B., Budaj A., Peters R.J., Bassand J.P., Wallentin L., Joyner C., Fox K.A. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med. 2006;354(14):1464-76. doi: 10.1056/NEJMoa055443.


Review

For citations:


Barbarash O.L., Kashtalap V.V. 2020 Russian and European clinical practice guidelines for the management of NSTEMI patients: have approaches to antithrombotic therapy been simplified? Complex Issues of Cardiovascular Diseases. 2021;10(2):92-101. (In Russ.) https://doi.org/10.17802/2306-1278-2021-10-2-92-101

Views: 407


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2306-1278 (Print)
ISSN 2587-9537 (Online)