EXPERIMENTAL MODEL OF CONGESTIVE LIVER IN RATS
https://doi.org/10.17802/2306-1278-2012-2-12-16
Abstract
Purpose. The study was aimed at examining structural and functional hepatic changes in an experimental model of chronic hepatic failure due to venous congestion.
Materials and methods. The experimental model of congestive liver was created in male Wistar rats. To model chronic venous congestion the left and intemediate hepatic veins were ligated. The model validity was assessed by biochemical and morphological criteria. In the liver of the experimental rats the signs of stasis, venous congestion, enlarged Disse's space, balloon dystrophy, impaired structure of the lobes and focal hepatocyte necrosis were observed. Statistically significant changes in the main biochemical markers of the functional liver condition showing hepatic failure development were registered in all the study timepoints: 4, 8 and 12 weeks. Those changes due to experimental chronic hepatic failure in their intensity and direction were similar to the changes in patients with tricuspid and mitral disorders.
Conclusion. This experimental congestive liver model can be used for examining liver condition in chronic venous congestion.
About the Authors
R. A. Mukhamadiyarov
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
N. L. Vorontsova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
Y. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
V. V. Borisov
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
I. Y. Zhuravleva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Mukhamadiyarov R.A., Vorontsova N.L., Kudryavtseva Y.A., Borisov V.V., Zhuravleva I.Y. EXPERIMENTAL MODEL OF CONGESTIVE LIVER IN RATS. Complex Issues of Cardiovascular Diseases. 2012;(2):12-16. (In Russ.) https://doi.org/10.17802/2306-1278-2012-2-12-16
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