PREVALENCE OF POLYVASCULAR DISEASE IN PATIENTS WITH ISCHEMIC HEART DISEASE

Purpose. To investigate the prevalence of polyvascular disease (PolyVD) depending on the diagnosis criteria.

Materials and methods. Seven hundred and thirty-two consecutive patients (586 men and 146 women), undergone CABG, were divided according to the number of affected arterial beds. The first definition of PolyVD was ≥ 30 % stenoses while the second one considered the lesions of ≥ 50 %. History, risk factors, laboratory and instrumental data were analyzed. Logistic regression was performed to reveal the influence of risk factors on the prevalence of PolyVD.

Results. In the first definition of PolyVD (≥ 30 %) one-bed lesions were found in 385 (52,6 %) and two or more in 347 patients (47,4 %). In the second definition of PolyVD (≥ 50 %) one-bed lesions were found in 531 (72,5 %) and two or more in 201 patients (27,5 %). In the first definition of PolyVD the probability of its detection declined with the increase in BMI (p = 0,022) and GFR (p = 0,025), and rose with the history of hypertension (p < 0,001) and smoking (p = 0,005), older age (p < 0,001) and intima-media thickness (IMT) (p < 0,001). In the second definition of PolyVD the probability of its detection was higher with smoking (p = 0,001), the history of hypertension (p = 0,001) and older age (p = 0,001). This probability is reduced with the increase in BMI (p = 0,007). In a multivariate analysis, regardless of PolyVD definition, age (p = 0,001), IMT (p < 0,001), smoking (p = 0,002) and hypertension (p = 0,008) retained their influence on the probability of PolyVD detection.

Conclusions. Before CABG PolyVD was diagnosed in 27,5 % of patients with ≥ 50 % stenoses and in 47,4 % of patients with ≥ 30 % stenoses. Risk factors associated with the prevalence of atherosclerosis are age, smoking, hypertension, IMT.

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