ENERGY DEFICIENCY OF PLATELETS IN PATIENS WITH ACUTE CORONARY SYNDROME IN COMBINATION WITH ANXIETY AND DEPRESSIVE DISORDERS
https://doi.org/10.17802/2306-1278-2016-4-73-80
Abstract
Purpose. We study of enzyme activity of blood platelets in patients with acute coronary syndrome (ACS) in a combination with anxiety and depressive disorders (ADD ).
Materials and methods. We examined 315 patients of both sexes in the first 24 hours of the ACS. There were 154 ACS patients without ADD and 161 patients with ADD . We researched the activity of the NAD and NADP-dependent dehydrogenases in platelets of the patients using bioluminescence assay methods in the first 24 hours after the patients’ admission and in the disease progress on the 10th day.
Results. A distinctive feature of the platelet metabolism in patients with ACS without ADD is a decreased level of aerobic respiration activity accompanied with the violation of interrelation between the Krebs cycle and reactions of amino acid metabolism while anaerobic respiration intensity is at a normal level. Patients who had ACS with ADD at all the stages of the examination had decreased activity of both anaerobic and aerobic respiration beside the disrupted connection between the products of amino acid metabolism and the Krebs cycle reactions.
Conclusion. ACS patients with ADD had a more pronounced change in the platelet energy metabolism, which may be one of the pathophysiological causes of the violation of the functional platelet activity in the hemostasis.
About the Authors
N. Yu. SHIMOKHINA
Krasnoyarsk State Medical University named after professor V. F. Voyno-Yasenetsky. Krasnoyarsk, Russia
Clinical Emergency Hospital name of N. S. Karpovich. Krasnoyarsk, Russia
Russian Federation
Russian Federation
Address: 1, Partizana Zheleznyaka st., Krasnoyarsk, 660022, Russian Federation Tel.: +7-923-456-93-92
A. A. SAVCHENKO
Krasnoyarsk State Medical University named after professor V. F. Voyno-Yasenetsky. Krasnoyarsk, Russia
Research Institute of Medical Problems of the North. Krasnoyarsk, Russia
Russian Federation
Russian Federation
M. M. РETROVA
Krasnoyarsk State Medical University named after professor V. F. Voyno-Yasenetsky. Krasnoyarsk, Russia
Russian Federation
Russian Federation
M. S. CHERNYAEVA
Krasnoyarsk State Medical University named after professor V. F. Voyno-Yasenetsky. Krasnoyarsk, Russia
Russian Federation
Russian Federation
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Review
For citations:
SHIMOKHINA N.Yu., SAVCHENKO A.A., РETROVA M.M., CHERNYAEVA M.S. ENERGY DEFICIENCY OF PLATELETS IN PATIENS WITH ACUTE CORONARY SYNDROME IN COMBINATION WITH ANXIETY AND DEPRESSIVE DISORDERS. Complex Issues of Cardiovascular Diseases. 2016;(4):73-80. (In Russ.) https://doi.org/10.17802/2306-1278-2016-4-73-80
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