Brain lymphatic drainage system – visualization opportunities and current state of the art
https://doi.org/10.17802/2306-1278-2020-9-3-81-89
Abstract
The lymphatic drainage system of the brain is assumed to consist of the lymphatic system and a network of meningeal lymphatic vessels. This system supports brain homeostasis, participates in immune surveillance and presents a new therapeutic target in the treatment of neurological disorders.
The article analyzes and systematizes data on the brain lymphatic drainage system. The key components of this system are considered: recently described meningeal lymphatic vessels and their relationship with the glymphatic system, which provides perfusion of the central nervous system with cerebrospinal and interstitial fluids. The lymphatic drainage system helps to maintain water and ion balances of the interstitial fluid and to remove metabolic waste products, assists in reabsorption of macromolecules. Disorders in its work play a crucial role in age-related changes in the brain, the pathogenesis of neurovascular and neurodegenerative diseases, as well as injuries and brain tumors. The review also presents the results of human studies concerning the presence, anatomy and structure of meningeal lymphatic vessels and the glymphatic system. The discovery of the brain lymphatic drainage system has not only changed our understanding of cerebrospinal fluid circulation, but also contributed to understanding the pathology and mechanisms of neurodegenerative diseases.
About the Authors
G. S. Yankova
Federal State Budgetary Institution of Science “Lavrentyev Institute of Hydrodynamics”, Siberian Branch
of the Russian Academy of Sciences;
Federal State Budgetary Educational Institution of Higher Professional Education “Novosibirsk National Research State University”
Russian Federation
Russian Federation
assistant researcher at the Laboratory of Differential Equations, 15, acad. Lavrenteva Ave., Novosibirsk, 630090;
assistant Professor at the Department of Mechanics and Mathematics, Pirogova St., Novosibirsk, 630090
O. B. Bogomyakova
Federal State Budgetary Institution of Science “International Tomographic Center”, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
PhD., MD, researcher at Laboratory of MRI technologies,
3а, Institutskaya St., Novosibirsk, 630090
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For citations:
Yankova G.S., Bogomyakova O.B. Brain lymphatic drainage system – visualization opportunities and current state of the art. Complex Issues of Cardiovascular Diseases. 2020;9(3):81-89. (In Russ.) https://doi.org/10.17802/2306-1278-2020-9-3-81-89
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