Assessment of calcium antagonist therapy protective effect on the thickness of the intima-media complex in patients with arterial hypertension
https://doi.org/10.17802/2306-1278-2021-10-2S-54-57
Abstract
Aim. To evaluate the connection of calcium antagonist (amlodipine) therapy with the dynamics of the intima-media complex thickness in patients with arterial hypertension (AH), depending on genetic polymorphism.
Methods. The study included representatives of the indigenous nationality (the Shors) – 901 people, of which a group of 367 people with hypertension was identified. The prospective stage of observation included 234 people who did not receive antihypertensive therapy. Based on the prescription of calcium antagonists, patients with hypertension were divided into two groups. Gene polymorphism was tested by polymerase chain reaction.
Results. In the Shor cohort, the regression of the intima-media complex thickness of the carotid arteries was observed more often in hypertensive patients who received calcium antagonists if to compare them with those who did not take the drug [OR = 2.30]. In addition, the decrease in the atherosclerotic process is associated with the genotype carriage: I/I of the ACE gene [OR = 9.42], T/C of the AGT gene [OR = 3.52], 4b/4b and 4b/4a of the eNOS gene [OR = 2.26 and OR = 3.75], C/C of the MTHFR gene [OR = 2.62].
Conclusion. Pharmacogenetic aspects are valuable from the point of view of an individual approach and obtaining the most pronounced pharmacological response in order to slow down the processes of vascular wall remodeling in patients with hypertension.
About the Authors
N. I. Morozova
Novokuznetsk State Institute for Further Training of Doctors – Branch of the State Educational Institution
for Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
assistant of the Department of Cardiology,
5, Stroiteley Ave., Novokuznetsk, 654005
T. A. Mulerova
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”
Russian Federation
Russian Federation
M.D., Associate Professor, Leading Researcher at the Laboratory of Cardiovascular Diseases Epidemiology, the Department of Medical Care Optimization for Cardiovascular Diseases,
6, Sosnoviy Blvd., Kemerovo, 650002
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Review
For citations:
Morozova N.I., Mulerova T.A. Assessment of calcium antagonist therapy protective effect on the thickness of the intima-media complex in patients with arterial hypertension. Complex Issues of Cardiovascular Diseases. 2021;10(2):54-57. (In Russ.) https://doi.org/10.17802/2306-1278-2021-10-2S-54-57
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