This study elucidates the main clinical results achieved with epoxy-treated (ethylene glycol diglycidyl ether) porcine valve bioprostheses. New technologies of biomaterial modifi cation and an innovative design of bioprosthetic valves are presented. The ways of further artifi cial valve development are discussed. 

The clinical and prognostic signifi cances of different degrees of non-coronary atherosclerosis in acute coronary syndrome (ACS) patients were reported in the study fi ndings. A high (95 %) prevalence of non-coronary atherosclerosis, the degree of which was progressing in more than 70 % of patients 12 months after ACS, was defi ned. Moreover, the clinical and prognostic importance of polyvascular disease (PolyVD) in ACS and the necessity of early detection of non-coronary atherosclerosis in ACS patients were determined to optimize risk estimation. Interleukin-12, tumor necrosis factor-α were considered to be the markers of subclinical infl ammation of polyvascular disease (PolyVD) and ACS; their possible application in modern statistical risk estimation models of ACS were suggested. The perspective areas in fundamental and clinical studies of polyvascular disease were proposed to the further research. 

Purpose. To evaluate coronary and heart failure course in patients with ischemic heart disease (IHD) and reduced left ventricular (LV) ejection fraction (EF) within 5 years after coronary stenting. Materials and methods. One hundred and seven patients with IHD and postinfarctLVdysfunction (NYHA II-III), who underwent coronary angioplasty, were examined. All the patients were divided into two groups: Group I included patients (n = 49) with reduced (≤ 45 %) LVEF; Group II consisted of 58 patients with preserved myocardial contractility. Myocardial perfusion, exercise capacity andLVremodeling before and 1, 3 and 5 years after revascularization were assessed. Results. Endovascular revascularization in patients with IHD and reducedLVfunction is highly clinically effective. Successful coronary stenting in patients with reduced LVEF provides a progressive improvement of myocardial contractility within 3 years by increasing EF and reducing end-diastolic pressure by an average of 19 (p = 0,018) and 24 % (p = 0,04) respectively. The use of stents with antiproliferative coating leads to the reduction in the incidence of restenosis by 10,2 % (p = 0,029) 1 year after stenting. However, during the same follow-up period Group I patients had the excess (4-fold) need for repeat myocardial revascularization compared with Group II (p = 0,026). At the same time no signifi cant differences between groups in overall frequency of repeat revascularizations at 3 and 5 years of follow-up have been reported. Conclusions. Coronary stenting in patients with postinfarct heart dysfunction, decreased LVEF (≤ 45 %) and symptoms of II-III NYHA CHF is a highly effective and safe treatment modality. 

 Purpose. The study was aimed at evaluating the impact of multipotent mesenchymal stromal cells derived from the marrow (MMSC) on the biodegradation speed of polyhydroxyalkanoate and polycaprolactone copolymer compositions potentially suitable for small vascular graft production. Materials and methods. The study compared fi lm scaffold (FS) № 1 made from 5 % polyhydroxybutirate and valerate and 10 % polycaprolactone (PCL) and fi lm scaffold (FS) № 2 made from 7,5 % polyhydroxybutirate and valerate and 10 % PCL. MMSC were derived from Wistar rat femoral bones. Results. The experiment showed that FS № 2 resorption started 2 months earlier than that of FS № 1 due to higher percentage of polyhydroxybutirate and valerate. Conclusions. The presence of MMSC delayed the start of copolymer scaffold bioresorption for 1 month and reduced the duration inflammatory response in the surrounding tissues. 

Purpose. The purpose of the study was to compare cardioprotective dose-dependent effects of liposomal and free emoxipine on cardiomyocytes in an isolated ischemized rat heart during reperfusion. Materials and methods. In the experiments on the isolated perfused rat heart the effects of liposomes containing different concentrations (0,25 and 0,1 mg/mL) of emoxipine on cardiomyocytes of the isolated heart after total normothermic ischemia and reperfusion were evaluated. The level of cardiac enzymes in the outfl owing perfusate and the morphology of the TUNEL-stained myocardium were assessed. Results. The obtained results showed that less liposomal emoxipine concentrations (0,1 mg/mL) led to the maximum decrease in reperfusion-induced myocyte sarcolemma injury in the ischemized myocardium during reperfusion. 

Purpose. Improvement of a demographic situation in theKemerovoregion by development and introduction of innovative klinikoorganizational approaches in activity of cardiological service. Materials and methods. System and situation analysis, comprehensive approach, modeling. Results. The adverse demographic situation in economically developed industrial region of the Siberian federal District of (Kemerovoregion) is caused by mainly high mortality of the population from diseases of system of blood circulation (DSBC). Among operated factors the important role is allocated for system of rendering of specialized medical care, in particular: to ensuring continuity in prevention, treatment and rehabilitation of patients with DSBC; to close interaction of doctors of primary link (therapist, surgeon) and specialized institutions (cardiologist, кардиохирург); to creation of conditions for introduction of scientifi c and reasonable modern clinical approaches in practice. More than two decades in gKemerovothe integration model of cardiological service based on technology of «the closed cycle» with participation of establishments of health care of municipal and federal levels, medical science and education was formed. Conclusions. Availability of specialized hi-tech medical care to the population allowed to increase introduction of the concept of the general ideology, it is rational to use health care resources, to develop creative cardiology and to broadcast results of basic scientifi c researches in practice that affected improvement of a demographic situation in the region. In2010 incomparison with 2005 mortality from DSBC at able-bodied age in Kuzbass decreased by 33,7 %. 

 Purpose. This study was aimed at examining the infl uence of thrombophilic conditions on pulmonary embolism (PE) and the effi cacy of thrombolytic therapy. Materials and methods. The effects of haemostatic disorders on the frequency of recurrent PE, phlebothrombosis and inferior vena cava thrombosis were studied in 70 patients with acute massive PE. Results. Hematogenic thrombophilia was detected in 25,7 % of patients. It was found that thrombosis and embolism in the vena cava fi lter were observed more frequently in patients with hematogenic thrombophilia than in patients with pulmonary embolism of unknown etiology. Conclusions. It was proved that differentiated treatment of hematogenic thrombophilias can signifi cantly reduce the risk of recurrent thrombotic episodes in patients with acute pulmonary embolism. 

 Purpose. The study was aimed at detecting the signs of focal and perifocal injury in venous strokes and their differences from those in arterial strokes by urgent CT and MRI. Materials and methods. The diagnosis of a venous stroke was verifi ed by neurovisualization (native MSCT, perfusion CT or CT angiography, conventional MRI and MR-angiography) and during autopsy (in case of a fatal outcome). Results. Patients with venous strokes had a hyperdense (by routine CT) stroke-related vessel, compensatory venous distention on the side of the occlusion, early haemorrhagic transformation, the changes localized in the region of the affected vein. Conclusions. The study allowed to detect CT and MRI signs, which can help to differentiate arterial and venous strokes.