Aim. To investigate the state of systemic hemodynamics (SHD) in young people to assess the potential impact of its disorders in the formation of arterial hypertension (AH) and to carry out preventive measures.

Methods. A random sample of 91 young people from 17 to 25 years old was examined; 27 of them were men (average age 23.7±1.6 years) and 64 women (average age 20.4±1.1 years). The study involved clinical residents and students who, according to preliminary and periodic medical examinations, excluded the presence of cardiovascular diseases. The indicators of SHD were investigated by the method of volumetric compression oscillometry using a portable automated software and hardware complex for non-invasive research of central hemodynamics (Device “CAP TsG osm-“Globus”).

Results. AH was detected in 4.4%; “white coat” AH in 8.79%; arterial hypotension – in 5.49%. In individuals with normal blood pressure (BP) (75 people), an increase in specific peripheral vascular resistance was most often revealed in 30.6%. An unchanged hemodynamic profile in the group with a normal BP level was recorded only in 28.0% of the examinees.

Conclusion. The obtained results indicate that even among “healthy” young people aged 18- 25 years with a normal BP level, the proportion of people with impaired SHD values is 72%. People with hypertension and with altered SHD indicators should be included in the regular medical check-up observation group. 

Aim. To assess the correspondence between the results of the European Social Survey (ESS) “The Impact of Medical Activity Bureaucratization on Professional Values of Personnel” and the results of sociological surveys of personnel of medical organizations such as Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases (NII KPSSZ) and Federal State Budgetary Institution “Kuzbass Clinical Cardiology Dispensary named after academician L.S. Barbarash” (GBUZ “KKKD”).

Methods. Comparative analysis of the results of ESS (3271 medical workers from 29 countries were questioned) and the results of sociological surveys of the medical personnel at NII KPSSZ (204 respondents in 2017) and at GBUZ “KKKD” (385 respondents in 2021) was carried out.

Results. According to the survey data of employees of NII KPSSZ the dominant values are: professionalism and conscientious attitude to work, respectful attitude to colleagues and patients, strict compliance with law and regulatory requirements. Among the main values of GBUZ “KKKD” staff the following were named: discipline and order in fulfilling responsibilities, professionalism and conscientious attitude to work, and respectful attitude to patients.

Conclusion. On the basis of the comparative analysis, the authors proved the validity of the conclusions and results of an international study devoted to the problem of the influence of bureaucratization of a medical organization on the structure of personnel values in medical organizations focused only on the treatment and diagnostic process. If an institution functions as a scientific and medical organization, then its employees tend to strive for professional self-development, innovative and creative thinking, which is not consistent with the conclusions of international researchers.

Aim. To establish the role of donor blood components which are used in the intraoperative period in children with septal congenital heart disease (CHD) who need surgical interventions with cardiopulmonary bypass (CPB) for the prevention of cerebral injury in the postoperative period.

Methods. 40 children of 14 months old on average and 8.8 kg of weight were under the study. All patients underwent radical correction of the septal CHD with the use of CPB. The patients were divided into 2 groups according to the donated blood components used. Cerebral damage was assessed with the help of three specific markers: protein S-100-ß, neuron-specific enolase (NSE) and glial fibrillar acidic protein (GFAP). The severity of the systemic inflammatory response was defined by the level of the following markers: interleukin 1, 6 and 10 in serum before operations, after the completion of IC and 16 hours after surgery. The clinical analysis of cerebral injury was performed via the Cornell Assessment for Pediatric Delirium.

Results. Statistically the concentration of all three markers of cerebral injury was significantly higher in the transfusion group after the end of CPB. Similar dynamics was observed in the concentrations of interleukins. In addition, the values for GFAP were higher in the transfusion group and 16 hours after surgery.

Conclusion. The safety and effectiveness of the strategy on refusal of intraoperative transfusion in order to prevent cerebral injury in children during the correction of septal CHD has been demonstrated. 

Aim. To compare the possibilities of venoarterial extracorporeal membrane oxygenation (VA ECMO) and intra-aortic balloon pump (IABP) to prevent organ damage and the development of multiple organ failure.

Methods. According to the inclusion and exclusion criteria, 51 patients underwent the study. The patients were divided into 2 groups depending on the method of mechanical circulatory support used: VA ECMO (n = 29) and IABP (n = 22). To assess organ functions in the intra- and postoperative period, the results of instrumental and laboratory research methods, as well as data from complex scales of organ dysfunction, were analased.

Results. Myocardial depression was observed in the IABP group in the intraoperative period of high-risk percutaneous coronary intervention and worse hemodynamic stability compared to the VA ECMO group was traced. Organ dysfunction and multiorgan failure developed more often in the IABP group, which was confirmed by laboratory specific markers.

Conclusion. High-risk percutaneous coronary intervention with VA ECMO is accompanied by a lower incidence and severity of organ damage and multiple organ failure. Thus, the VA ECMO has better organ protective effects. 

Aim. To identify the expression and possible sources of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in bioprosthetic heart valves (BHVs).

Methods. The material for the study was epoxy-treated BHVs (NeoKor Ltd, Kemerovo) obtained during valve re-prosthetics. Cellular infiltration and ECM degradation were assessed by haematoxylin and eosin staining while lipid deposition and calcification were analysed by Oil Red O and Alizarin Red S staining. Сellular typing and detection of MMP-1/-2/-8/-9/-12 and TIMP-1/-2 expression in samples were performed using immunohistochemical staining with antibodies to CD45, CD68, СD3, CD19, myeloperoxidase, and to the corresponding MMPs and TIMPs. Analysis of samples was performed by light microscopy.

Results. We examined 7 xenoaortic and 7 xenopericardial BHVs which were removed during re-replacement from the aortic (n = 2) and mitral (n = 12) positions. In studied leaflets from 13 explanted BHVs, sporadic infiltrates consisting of macrophages and neutrophils were revealed. Semi-quantitative analysis showed that more aggressive cellular infiltration is characteristic of xenoaortic BHVs (p = 0.038). MMP-1/-2/-8/-12 and TIMP-1/-2 were weakly expressed and co-localised with infiltrating cells whilst MMP-9 was abundant in the loosened extracellular matrix (ECM) devoid of host cells.

Conclusion. The recipient cells infiltrating BHVs are sources of MMP-1/-2/-8/-9/-12 and TIMP-1/-2. In addition, MMP-9 can diffuse into BHVs leaflets from the blood of patients. 

Background. Preclinical tests of biodegradable small diameter vascular prostheses on a sheep model have been carried out.

Aim. To assess the results of long-term patency and remodeling of biodegradable vascular prostheses based on polyhydroxybutyrate / valerate and polycaprolactone with an atrombogenic drug coating in a large laboratory animal model.

Methods. We researched vascular prostheses made of polyhydroxybutyrate / valerate and polycaprolactone (PHBV/PCL) 4 mm in diameter with layer-by-layer vascular endothelial growth factor incorporated into the polymer framework, the main fibroblast growth factor, chemoattractant molecule containing SDF-1a (GFmix) surface, and additional modifying drug surface heparin and iloprost (PHBV/PCL/ GFmix/Heparin/Iloprost). Animals with implanted synthetic Gore-Tex vascular grafts with a diameter of 4 mm were included into a comparison group.

Results. After one day of implantation it was revealed that the patency of biodegradable PHBV/PCL/GFmix/Heparin/Iloprost prostheses was 62.5%, while synthetic Gore-Tex prostheses were thrombosed in 100% of cases. At the same time, after 18 months of implantation, the patency of biodegradable vascular PHBV/PCL/ GFmix/Heparin/Iloprost prostheses decreased to 50%. Passable drug-eluting polymer grafts were completely resorbed after 18 months of implantation, and aneurysmically expanded newly formed vascular tissue was formed in their place.

Conclusion. Vascular prostheses made of polyhydroxybutyrate/valerate and polycaprolactone showed better long-term patency results than synthetic prostheses used in the clinical practice. However, the strengthening of the external framework of the prostheses is required in order to prevent the formation of aneurysms. 

Aim. To identify the factors influencing the development of postoperative atrial fibrillation (POAF).

Methods. The study included 100 patients with indications for cardiac surgery, aged 53 to 82 years (mean age 67.2±17 years). The group included patients who had no history of AF before surgery. Cardiac surgery in the group was presented in 63 patients by coronary artery bypass grafting, and in 37 – by intervention on the heart valves. All respondents were divided into 2 groups: the first included 39 people (39%) who had AF paroxysms lasting more than 30 seconds in the early postoperative period, with a peak at 1–2 days, in 13 (33.3%) cases of AF relapsed. The second group of patients was represented by 61 patients (61%) without cardiac arrhythmias after surgery.

Results. The dependence of the development of POAF on age, the concentration of C-reactive protein in the peripheral blood taken on the day of cardiac surgery, the longitudinal size of the left atrium before surgery was revealed.

Conclusion. It was found out that a number of factors such as age, preoperative left atrium size, C-reactive protein level in the first days after surgery suggest the development of POAF. The use of the predictors obtained can make it possible to develop an effective strategy for the prevention of POAF. 

Aim. To cоmpare the results оf infra-spinal reconstructions of the lower extremities with the formatiоn of a distal anastomоsis below the knee joint fissure with the use of a bioprosthesis and autovein in critical limb ischemia (CLI).

Methods. The hospital results of revascularization were retrospectively analyzed in 53 patients with CLI who underwent primary prosthetics of the femoral-popliteal segment with the fоrmation of a distal anastomоsis belоw the knee joint gap. All patients, depending on the prоsthetic material used, were divided into two groups: 1) autovein was used as a prosthesis (39.6%, n = 21)) and 2) a bioprosthesis was used (“KemAngioprosthesis” closed joint-stock company “NeoCor” Kemerovo, Russia) (60.4%, n = 32).

Results. In the early postoperative period, thrombosis developed in group 1 in 7 cases (33.3%): in 5 patients – on the first day after the surgery; 2 out of 5 patients were with chronic arterial insufficiency (CAI) of the fourth degree, 1 was with acute arterial insufficiency of the first degree, and 2 patients with the third degree of CAI. In group 2, there were 6 prosthetic thrombosis (18.7%), 4 cases of which developed thrombosis on the first day, 3 patients with CAI of the fourth degree and 1 case with acute arterial insufficiency of the second degree.

Conclusion. The application of infra-lingual reconstructions using bioprostheses is quite effective and safe in patients with CLI, in particular with purulent-necrotic trophic processes when a suitable autovein to be used as a prosthetic material is absent.

Aim. To evaluate the hospital results of one-stage radical correction (RC) of Fallot's tetrad (TF) and stage-by-stage correction of the defect using stenting of the right ventricular outflow tract (RVOT).

Methods. The group of step-by-step correction included 24 patients with the classic cyanotic form of TF: 1st stage – stenting of the RVOT (Me age 73.5 days, weight 3.8 kg), 2nd stage – RC of TF Me age 187 days. The group of one-stage RC TF included 30 newborns with Me aged 121.5 days and weight 5.5 kg.

Results. After performing stenting of RVOT, there was a significant increase in SpO2 from 80 to 94%, end diastolic volume of left ventricle index from 24 to 33.3 ml/m2 , a decrease in the severity of hypoplasia of the pulmonary artery trunk (PA) compared with the stage before stenting of RVOT (p˂ 0.05). Patients of the two groups had equal values of weight, SpO2, the severity of PA hypoplasia, and a gradient in the RVOT at the time of RC. After the RC in stenting group there was an increase in SpO2 up to 98%, a decrease in the RVOT gradient from 75 to 16.5 mm Hg, an increase in the end diastolic volume left ventricle index to 56.5 ml/m2 (p˂ 0.05). The dynamics of the status of patients in Group 1 with the use of palliative intervention did not significantly differ from the dynamics in Group 2 (one-stage RC TF).

Conclusion. Application of the approach of step-by-step correction of TF with stenting of RVOT in low weight infants with severe hypoxemia demonstrated an equal effect on the dynamics of SpO2, reverse cardiac remodeling compared with patients who underwent simultaneous RC of classical TF.

Aim. To evaluate the connection of calcium antagonist (amlodipine) therapy with the dynamics of the intima-media complex thickness in patients with arterial hypertension (AH), depending on genetic polymorphism.

Methods. The study included representatives of the indigenous nationality (the Shors) – 901 people, of which a group of 367 people with hypertension was identified. The prospective stage of observation included 234 people who did not receive antihypertensive therapy. Based on the prescription of calcium antagonists, patients with hypertension were divided into two groups. Gene polymorphism was tested by polymerase chain reaction.

Results. In the Shor cohort, the regression of the intima-media complex thickness of the carotid arteries was observed more often in hypertensive patients who received calcium antagonists if to compare them with those who did not take the drug [OR = 2.30]. In addition, the decrease in the atherosclerotic process is associated with the genotype carriage: I/I of the ACE gene [OR = 9.42], T/C of the AGT gene [OR = 3.52], 4b/4b and 4b/4a of the eNOS gene [OR = 2.26 and OR = 3.75], C/C of the MTHFR gene [OR = 2.62].

Conclusion. Pharmacogenetic aspects are valuable from the point of view of an individual approach and obtaining the most pronounced pharmacological response in order to slow down the processes of vascular wall remodeling in patients with hypertension. 

Aim. To analyze the results of various revascularization techniques in high-risk non – STsegment elevation in acute coronary syndromes performed during the first 24 hours.

Methods. As a part of a single-center retrospective study, 45 cases of coronary artery bypass grafting (CABG) were examined in high-risk non – ST-segment elevation in acute coronary syndromes patients during the first 24 hours since their hospitalization for the period from 2017 to 2020. 45 cases of percutaneous coronary intervention (PCI) were selected from a similar group of patients with the help of the copy-pair method.

Results. The groups were comparable according to such significant factors as age, gender, postinfarction cardiosclerosis, diabetes mellitus, and multifocal atherosclerosis. However, the severity of coronary atherosclerosis according to the Syntax score was significantly higher in the CABG group (p = 0.0004). The groups were comparable in achieving complete revascularization (p = 0.2). In 8.9% (n = 4) of patients in the PCI group, unscheduled repeated revascularization was required, and in 15.6% (n = 7) of cases stent restenosis/thrombosis was detected during the hospital period and between PCI stages, while in the CABG group, congenital malformations and dysfunction were not found. Mortality in the groups did not differ significantly (4 (8.8%) versus 2 (4.4%), p = 0.4).

Conclusion. CABG provides freedom from repeated revascularizations, despite the initially more severe coronary lesion. 

Aim. To develop an algorithm for the automated functional design of the heart valve leaflet apparatus.

Methods. The geometry of the aortic valve leaflet was designed in the Matlab programming environment (MathWorks, Massachusetts, USA). Numerical modeling of the opening process was performed using Abaqus/CAE (Dassault Systemes, France).

Results. We developed an algorithm, with the help of which a set of models of the leaflet apparatus was designed. 8 models were subjected to numerical modeling of the stress-strain state. The locking pressure simulation has shown that the smallest von Mises stress value was recorded for a sample with a larger surface area of the leaflet belly and it equals 0.422 MPa. The results obtained show that the value of the radius of curvature significantly affects the behavior of the entire valve, which leads to the conclusion that it is necessary to carefully select the design of the valve apparatus for its correct functioning.

Conclusion. The study provides the primary confirmation that the concept of the algorithm is efficient for the automated functional design of the aortic heart valve leaflet apparatus. 

Aim. To analyze and study the possibility of using an innovative approach to managing patient interaction such as design-thinking technology in the activities of a medical organization to improve medical care for cardiovascular disease.

Methods. To achieve the goal the analysis of the domestic and foreign literature, and the normative-legal documentation for the period from 2015 to 2020 was carried out. The base of the research was Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo), where medical, scientific, educational and publishing activities are successfully implemented.

Results. Based on the studied theoretical ideas about the essence of the considered technology, the authors formulated the definition of design-thinking in health care, which is understood as a set of activities aimed at improving the process of providing medical aid by studying and maximizing satisfaction of the patient’s needs. The stages of the technology are outlined and described: empathy, generation of ideas, solution development, prototyping on the example of a research base.

Conclusion. The technology of design-thinking can organizationally and functionally supplement the process of interaction management with patients, and regular evaluation of the level of satisfaction is an initial stage of implementing an innovative approach. 

Aim. To study the features of clinical and anamnestic characteristics and treatment of patients with hypertriglyceridemia (HTG) using the data of the lipid control center of Kemerovo.

Methods. The single-center retrospective study is based on the data of patients dynamic observation (n = 100) in the Dyslipidemia Registry of Kuzbass in 2019. A comparative analysis of clinical and anamnestic characteristics, lipidogram parameters and therapy was performed at the time when the patients were included in the study and after 6–12 months in patients with HTG (the criterion was the level of triglycerides (TG) above 1.69 mmol/L) and in patients without it. Indications for consulting a lipidologist were high cholesterol (levels of total cholesterol (TC) ˃7.5 mmol/L or low-density lipoprotein cholesterol ˃4.9 mmol/L or TG˃5 mmol/L), requirement of the high dose and/or combination therapy of lipid-lowering drugs; medical history of cardiovascular diseases and/or revascularization of vascular bed in patients under 55 years of age; suspected intolerance to lipid-lowering therapy due to the developed side effects; the issue of lipid-lowering therapy in complex clinical situations.

Results. Among the patients who visited a lipidologist in 2019, mixed hypertriglyceridemia was noted in 56 (56%) of cases, while 44 (44%) patients had other lipid metabolism disorders without increased levels of TG. A distinctive feature of patients with mixed hypertriglyceridemia is the lower incidence of myocardial infarctions (p = 0.029) and lower number of coronary stents (p = 0.018) in the medical history, despite the initially higher levels of TC (p = 0.005) and TG (p = 0.000). According to the results of 6–12 months observation, a significant decrease in TC (p = 0.001) and TG (p = 0.044) levels during the lipid-lowering therapy was revealed due to the addition of fenofibrate (p = 0.000) to all groups of patients who were monitored by a lipidologist.

Conclusion. The patients with dyslipidemia and HTG are a complex category of patients who require combined lipid-lowering therapy, which can only be prescribed by a lipidologist. 

Aim. To analyze and scientifically substantiate the need for the creation of a program for the outpatient observation with COZANC using remote patronage.

Methods. The study prospectively included 150 patients with atherosclerosis of the arteries of the lower extremities. The average age of the patients was 68.3 ± 9.7 years. Clinical and anamnestic data were studied, and patients were interviewed using questionnaires and scales. Two observation groups were formed: the main one consisted of 70 patients, who were included in the program of remote patronage clinical examination, and 80 patients were under the standard model of outpatient observation with COZANC.

Results. For a 3-month period of outpatient observation, an audio communication session was carried out for 70 patients, once a month. During the reporting period, no acute cardiovascular events were recorded in the main group, while in the comparison group there were 3 (3.75%) myocardial infarctions. The development of CLI occurred in the main group in 1 case, while in the comparison group there were 4 (5%) patients, in one case the lower limb was amputated. In the comparison group, there were 3 ischemic events that resulted in a lethal outcome.

Conclusion. For the first time, a personalized remote patronage program was created and introduced into clinical practice at the level of primary health care, as a tool for optimizing the clinical examination program for patients with COZANC. The effectiveness of the remote patronage program for patients with atherosclerosis of the arteries of the lower extremities is described in relation to the prevention of acute cardiovascular events and the progression of COZANC. 

Aim. To study “the portrait” of patients with acquired mitral valve (MV) heart disease of various origins and pulmonary hypertension hospitalized for surgical correction of the defect.

Methods. The study included 97 patients with acquired diseases of mitral valve and pulmonary hypertension. The assessment of demographic, clinical and anamnestic data, indicators of transthoracic echocardiography, quality of life before the correction of MV defect was carried out.

Results. The studied cohort is mostly represented by female patients (n = 70; 72.2%). The most common cause of mitral valve disease was rheumatic heart disease (n = 40; 41.2%). Overweight, hypertension (n = 76; 78.4%) and atrial fibrillation (n = 62; 63.9%) were the most common comorbidities. The mean pressure level in the pulmonary artery according to echocardiography was 35.5 (29.0; 40.0) mm Hg, with no significant difference among the patients, regardless the mitral defect etiology. Less pronounced remodeling of the left ventricle was noted in patients with rheumatic heart disease, which is caused by a lesion of the MV by the type of stenosis in contrast to patients with connective tissue dysplasia syndrome or against the background of detachment of MV chords with MV damage in the form of its insufficiency. There were no significant differences in the systolic function of the right ventricle depending on the etiology of MV defect.

Conclusion. The “portrait” of a patient with pulmonary hypertension associated with an acquired mitral valve defect before its correction is the predominance of female, overweight, with II or III functional class of chronic heart failure, more frequent rheumatic genesis of MV defect, the presence of concomitant pathology in the form of hypertension and persistent atrial fibrillation, and increased size of the left atrium and left ventricle, reduced systolic function of the right ventricle according to the data of Echocardiography. 

Aim. To create a personalized cell-populated small-diameter vascular prosthesis in a pulsating bioreactor.

Methods. Tubular grafts were made by electrospinning from mixtures of biodegradable polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(εcaprolactone) (PCL). The inner surface is modified with fibrin. Tubular scaffolds were colonized with cultured colony-forming endothelial cells and grown under static conditions for 2 days. Then, the cell-populated prostheses continued to be cultivated for 5 days in a pulsating bioreactor system with a final shear stress of 2.85 dynes/cm².

Results. The advantages of the cultivation of cell-populated vascular prostheses in a pulsating bioreactor have been revealed. The selected mode of cultivation of cellpopulated vascular prostheses under conditions of a pulsating flow with a shear stress of 2.85 dynes/cm² did not have a damaging effect on the integrity of the endothelial monolayer. Moving unidirectional mechanical stimuli of chaotic orientation fibers of F-actin changed to a predominant orientation in the direction of flow, and also increased the expression of F-actin, Talin focal adhesion protein, and specific endothelial markers CD309, CD31, vWF.

Conclusion. The creation of a personalized cell-populated small-diameter vascular prosthesis with a functional endothelial monolayer is possible due to the use of autologous endothelial cells, autologous fibrin, and cultivation under conditions of a pulsating flow.

Aim. To carry out a comparative assessment of cardiometabolic risk factors in men and women aged 18–44 years.

Methods. The cross-sectional study included 251 patients divided into 2 groups. Group 1 consisted of 124 men; group 2 had 127 women in it. All participants of the study underwent anamnesis collection, blood pressure measurement, and assessment of anthropometric parameters, physical examination, biochemical and immunological tests.

Results. The most significant gender differences were noted in the levels of leptin and adiponectin, fibrinogen and plasminogen activator inhibitor type 1, angiotensin II and interleukin-10 in the blood serum with no differences in cardiometabolic risk factors, including glucose and lipid metabolism.

Conclusion. The revealed features of changes in adipokines and cytokines, indicators of hemostasis and vasoconstrictors in men and women expand the current knowledge about the role of some pathophysiological mechanisms in the development of cardiovascular pathology at a young age in the context of cardiometabolic risk concept. 

Aim. To develop and evaluate the safety/efficacy of an early rehabilitation program with physical aerobic training in patients after surgical repair of acquired valvular heart disease.

Methods. The study included 45 patients with valvular heart disease undergoing surgical repair. Patients in the group (n = 30) underwent a standard cardiac rehabilitation after the surgery; on the 8th day after the surgery patients in the main group (n = 15) in addition to the standard cardiac rehabilitation were involved in personalized aerobic physical training on a treadmill prescribed according to the cardiopulmonary exercise testing results (spiroveloergometry). The duration of the training on a treadmill was 14 days.

Results. The rhythm changing, life-threatening heart rhythm disorders, episodes of ischemia, desaturation were not recorded during the training. The main reason to stop the training was the weakness and fatigue of the patients. There were no disturbances of intracardiac hemodynamic after the course of physical training. In the main group there was a significant increase in exercise tolerance from 50.0 [25.0; 75.0] to 75.0 [50.0; 100.0] W (p = 0.04), close to significant increase in VO2peak from 10.9 [9.6; 13.3] to 12.3 [10.6; 14.9] ml/kg/min (p = 0.07).

Conclusion. The 14-days program of early rehabilitation with aerobic training after surgical repair of valvular heart disease has demonstrated its safety and influenced the increase in exercise tolerance, peak oxygen consumption. 

Aim. To assess the dynamic changes and clinical significance of biomarkers of inflammatory processes in patients with acute myocardial infarction (MI) with/ or without type 2 diabetes mellitus (T2DM) and primary percutaneous coronary intervention (pPCI) at various stages of treatment.

Methods. 96 patients with acute MI after pPCI were examined. The level of inflammation markers was measured 4 times: before pPCI (first day from admission to the hospital), on the third day, 7–10 days (before discharge from the hospital) and 40–45 days after pPCI.

Results. All groups of patients with MI showed an increase in the plasma activity of biomarkers of inflammatory processes. After pPCI for 40–45 days, there is a significant difference in the concentration of biomarkers, depending on the comorbid T2DM presence. Strong associations were found between cardiovascular biomarkers and post-MI cardiac remodeling and coronary atherosclerosis progression.

Conclusion. The assessment of the levels of biomarkers of inflammatory processes may have additional clinical value in estimating the course of MI, including patients with T2DM at the postinfarction stages.